Diverin^®

Diverin ® is a preparation of Dicycloverine Hydrochloride. It has anticholinergic and antimuscarinic effect.

No Data

Diverin ® is indicated for symptomatic relief of spasmodic pain associated with intestinal colic, dysmenorrheal, functional and irritable bowel syndrome, uninary incontinence secondary to unstable detrusor muscle, infantile colic.

Route of administration: Diverin® should be taken orally.
Adult: 10-20 mg three times daily.
Children (2-12 years): 10 mg three times daily.
Infant (6 months-2 years): 5-10 mg (0.5 - 1 teaspoonful syrup) three times daily, 15 minutes before feed.

Pregnancy: Dicycloverine should be used during pregnancy only if clearly needed. No teratogenic effect was shown in animal study.

Lactation: Since dicycloverine hydrochloride has been reported to be secreted in human milk. So, dicycloverine is contraindicated in lactating mother.

Use in children and adolescents
Dicycloverine should not be used under 6 months of age.

Dicycloverine should be used with caution in patient with autonomic neuropathy, hepatic or renal disease, ulcerative colitis; large doses may suppress intestinal motility to the point of producing a paralytic ileus and the use of this drug may precipitate or aggravate the serious complication of toxic megacolon, hyperthyroidism, hypertension, coronary heart disease, congestive heart failure, cardiac tachyarrhythmia, hiatal hernia, known or expected prostatic hypertrophy.

Side effects include constipation, transient bradycardia (followed by tachycardia, palpitations and arrhythmias), reduced bronchial secretions, urinary urgency and retention, dilatations of the pupils with loss of accommodation, photophobia, dry mouth, flushing and dryness of the skin.

Dicycloverine is contraindicated in patients with known hypersensitivity to dicycloverine or any components of this product. It is also contraindicated in angle closure glaucoma, myasthenia gravis, pyloric stenosis, paralytic ileus, prostatic enlargement, obstructive uropathy, obstructive disease of gastrointestinal tract, severe ulcerative colitis and reflux esophagitis.

Drug interaction with medication: The following agents may increase certain actions or side effects of anticholinergic drugs: amantadine, antiarrhythmic agent of class 1 (e.g., quinidine), antihistamines, antipsychotic agents (e.g., phenothiazines), MAO inhibitors, narcotic analgesics (e.g., meperidine), nitrates and nitrites, sympathomimetic agents, tricyclic antidepressants and other drugs having anticholinergic activity. Dicycloverine may affect the gastrointestinal absorption of various drugs, such as digoxin, metoclopramide.
Drug interaction with food and others: Not applicable.

The signs and symptoms of overdose are headache, nausea, vomiting, blurred vision, dilated pupils, hot and dry skin, dizziness, dryness of the mouth, difficulty in swallowing and CNS stimulation. Treatment should consist of gastric lavage, emetics and activated charcoal. Sedatives (e.g., short acting barbiturates, benzodiazepines) may be used for the management of overt signs of excitement. If indicated, an appropriate cholinergic agent may be used as an antidote.

No Data

Diverin® tablet: Store in a cool (below 30°C) and dry place protected from light. Keep away from the reach of children.
Diverin® syrup: Store in a cool (below 25°C) and dry place protected from light. Keep away from the reach of children.

No Data

Diverin^® 10 mg tablet: Carton of 50 tablets in blister pack.

Diverin^® 20 mg tablet: Carton of 50 tablets in blister pack.

Diverin^® syrup: Bottle of 50 ml.