Lotensin^®

Lotensin® is the preparation of Timolol Maleate. lt is a nonselective β-blocker. Lotensin® has the action of reducing elevated intraocular pressure,whether or not accompanied by glaucoma. The action of Lotensin® is usually rapid, occurring approximately 20 minutes following ocular instillation and maximum effect occurs in one to two hours.

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Lotensin ® is used in the following conditions :

• Ocular hypertension
• Chronic open-angle glaucoma
• Aphakic and secondary glaucoma

Adult:The usual starting dose is one drop of 0.5% Lotensin ® in the affected eye twice a day. lf the intra ocular pressure is maintained at satisfactory level,the dosage schedule may be changed to one drop once a day. Since in some patients the pressure lowering response to Lotensin ® may require a few weeks to stabilize, evaluation should include a determination of intra ocular pressure after approximately 4 weeks of treatment with Lotensin ®
Children: Timolol Maleate is not recommended in premature baby and newborn because clinical studies in children have not been conducted.

Pregnancy
Timolol Maleate has not yet been studied in human pregnancy. Lotensin ® eye drop should therefore not be used during pregnancy unless there is a clear benefit.
Lactation
β-bolckers are excreted in the milk.The risk of hypoglycemia and bradycardia in nursing infants has not been evaluated.Breast-feeding is not recommended during treatment.

Precautions should be taken with bronchospastic disease,congestive cardiac failure.Withdraw drug gradually if β-blocker side effects e.g. skin rash, dry eyes occur.

Systemic absorption may follow topical application therefore Lotensin ® is contraindicated in patients with bradycardia, heart block or uncontrolled heart failure.

Since systemic absorption may follow topical application the possibility of interactions persists. Ophthalmic supervision is required in case of concomitant therapy with eye drops containing adrenaline (mydriasis may occur).

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Store in a cool dry place. Protect from light.

Timolol Maleate is a β-adrenergic receptor blocking agent. lt is a clear isotonic solution that is sterile until the bottle is opened. Lt contains Timolol 0.5% as Maleate BP.